GHK-Cu

GHK-Cu is a naturally occurring copper-binding tripeptide (Glycyl-L-Histidyl-L-Lysine) complexed with copper(II) ions (Cu²⁺). First isolated from human plasma by Dr. Loren Pickart in 1973, GHK-Cu concentration in plasma decreases significantly with age — approximately 200 ng/mL at age 20 declining to 80 ng/mL by age 60.Laboratory research has investigated GHK-Cu's role in gene expression modulation — studies suggest it may influence the expression of over 4,000 genes. In-vitro research has examined its effects on extracellular matrix (ECM) components including collagen I, III, and IV synthesis, decorin expression, glycosaminoglycan production, and metalloproteinase regulation. Additional studies have explored its interaction with fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), and transforming growth factor beta (TGF-β) pathways.Molecular Weight: 403.93 g/mol. Complex: GHK:Cu(II) 1:1 stoichiometry. Appearance: Blue lyophilized powder. Solubility: Freely soluble in water. Storage: -20°C, lyophilized, sealed and protected from light.