PT-141

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH) and a metabolite of Melanotan II. Unlike MT-II, PT-141 acts primarily through melanocortin-3 and melanocortin-4 receptor (MC3R/MC4R) pathways in the central nervous system rather than peripheral melanocortin receptors.Laboratory research has investigated PT-141's selective agonist activity at MC3R and MC4R subtypes, its effects on hypothalamic neuron signaling, and its interaction with dopaminergic pathways. In-vitro binding studies demonstrate higher selectivity for MC4R compared to MC1R, distinguishing its receptor profile from that of Melanotan II. Research has also examined its pharmacokinetics and metabolic stability in various experimental systems.Molecular Weight: 1025.18 g/mol. Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH. Appearance: White lyophilized powder. Solubility: Soluble in water. Storage: -20°C, lyophilized, sealed and protected from light.