Selank

Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg) with a Pro-Gly-Pro C-terminal extension for enhanced stability. Developed at the Institute of Molecular Genetics, Russian Academy of Sciences — the same laboratory that created Semax — Selank is structurally complementary to Semax but acts through distinct receptor pathways.Laboratory research has investigated Selank's modulation of enkephalinase activity and its effects on endogenous opioid peptide metabolism (Met-enkephalin, Leu-enkephalin). In-vitro studies have examined its interaction with GABAergic neurotransmission, specifically GABA-A receptor complex modulation. Research has also explored its effects on monoamine neurotransmitter balance (serotonin, dopamine, norepinephrine), IL-6 expression in immune cell models, and BDNF/trkB signaling pathways in neuronal cultures.Molecular Weight: 751.88 g/mol. Sequence: TKPRPGP. Appearance: White lyophilized powder. Solubility: Soluble in water. Storage: -20°C, lyophilized, sealed and protected from light.